fuckyeahmolecularbiology: Model for the DNA binding and cleavage fragment of yeast topoisomerase II (blue/red spheres) bound to a separated DNA strand (green spheres). One protomer is shaded darker than the other to highlight the protein’s two subunits. A second DNA (viewed end-on, yellow sticks) is modeled into a large internal hole present in the enzyme. This figure represents a likely conformational and substrate-bound intermediate of this region of the topoisomerase during its duplex DNA passage reaction.
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fuckyeahmolecularbiology:

Model for the DNA binding and cleavage fragment of yeast topoisomerase II (blue/red spheres) bound to a separated DNA strand (green spheres). One protomer is shaded darker than the other to highlight the protein’s two subunits. A second DNA (viewed end-on, yellow sticks) is modeled into a large internal hole present in the enzyme. This figure represents a likely conformational and substrate-bound intermediate of this region of the topoisomerase during its duplex DNA passage reaction.

(via amolecularmatter)

Source: nsf.gov

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